USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q14116 USC-OGP 2-DE database:  Q14116 Q14116 General information about the entry View entry in simple text format Entry name IL18_HUMAN Primary accession number Q14116 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Interleukin-18; Short=IL-18; AltName: Full=Iboctadekin; AltName: Full=Interferon gamma-inducing factor; Short=IFN-gamma-inducing factor; AltName: Full=Interleukin-1 gamma; Short=IL-1 gamma; Flags: Precursor;. Gene name Name=IL18 Synonyms=IGIF, IL1F4 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0216: pI=4.53; Mw=21326 Cross-references UniProtKB/Swiss-Prot Q14116; IL18_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IL18_HUMAN Primary accession number Q14116 Secondary accession number(s) O75599 Q6FGY3 Q6WWJ7 Sequence was last modified on  November 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 160) Name and origin of the protein Description RecName: Full=Interleukin-18; Short=IL-18; AltName: Full=Iboctadekin; AltName: Full=Interferon gamma-inducing factor; Short=IFN-gamma-inducing factor; AltName: Full=Interleukin-1 gamma; Short=IL-1 gamma; Flags: Precursor; Gene name Name=IL18 Synonyms=IGIF, IL1F4 Encoded on Name=IL18; Synonyms=IGIF, IL1F4 Keywords 3D-structure; Alternative splicing; Complete proteome; Cytokine; Reference proteome; Secreted. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D49950; BAA08706.1; -; mRNA EMBL AY266351; AAP92112.1; -; mRNA EMBL AF077611; AAC27787.1; -; mRNA EMBL AY044641; AAK95950.1; -; mRNA EMBL CR541973; CAG46771.1; -; mRNA EMBL CR542001; CAG46798.1; -; mRNA EMBL AP002007; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471065; EAW67184.1; -; Genomic_DNA EMBL BC007007; AAH07007.1; -; mRNA EMBL BC007461; AAH07461.1; -; mRNA EMBL U90434; AAB50010.1; -; mRNA CCDS CCDS44731.1; -. [Q14116-1]; . CCDS CCDS58180.1; -. [Q14116-2]; . RefSeq NP_001230140.1; NM_001243211.1. [Q14116-2]; . RefSeq NP_001553.1; NM_001562.3. [Q14116-1]; . RefSeq XP_011541107.1; XM_011542805.1. [Q14116-2]; . RefSeq XP_011541108.1; XM_011542806.2. [Q14116-1]; . UniGene Hs.83077; -; . PDB 1J0S; NMR; -; A=37-193 PDB 2VXT; X-ray; 1.49 A; I=37-193 PDB 3F62; X-ray; 2.00 A; B=37-193 PDB 3WO2; X-ray; 2.33 A; A/B/C/D=37-193 PDB 3WO3; X-ray; 3.10 A; A/C/E/G/I/K=37-193 PDB 3WO4; X-ray; 3.10 A; A=37-193 PDB 4EEE; X-ray; 2.71 A; B/D=37-193 PDB 4EKX; X-ray; 1.75 A; B/D=37-193 PDB 4HJJ; X-ray; 2.10 A; A=37-192 PDB 4R6U; X-ray; 2.80 A; B/D=37-193 PDB 4XFS; X-ray; 1.91 A; A/B=37-193 PDB 4XFT; X-ray; 2.00 A; A/B=37-193 PDB 4XFU; X-ray; 2.85 A; A/B=37-193 PDBsum 1J0S; -; . PDBsum 2VXT; -; . PDBsum 3F62; -; . PDBsum 3WO2; -; . PDBsum 3WO3; -; . PDBsum 3WO4; -; . PDBsum 4EEE; -; . PDBsum 4EKX; -; . PDBsum 4HJJ; -; . PDBsum 4R6U; -; . PDBsum 4XFS; -; . PDBsum 4XFT; -; . PDBsum 4XFU; -; . ProteinModelPortal Q14116; -; . SMR Q14116; -; . BioGrid 109819; 11; . DIP DIP-3785N; -; . IntAct Q14116; 3; . STRING 9606.ENSP00000280357; -; . iPTMnet Q14116; -; . PhosphoSitePlus Q14116; -; . BioMuta IL18; -; . DMDM 3219817; -; . OGP Q14116; -; . EPD Q14116; -; . MaxQB Q14116; -; . PaxDb Q14116; -; . PeptideAtlas Q14116; -; . PRIDE Q14116; -; . DNASU 3606; -; . Ensembl ENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]; . Ensembl ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]; . Ensembl ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]; . GeneID 3606; -; . KEGG hsa:3606; -; . UCSC uc001pnb.2; human. [Q14116-1]; . CTD 3606; -; . DisGeNET 3606; -; . GeneCards IL18; -; . HGNC HGNC:5986; IL18; . HPA CAB007772; -; . HPA HPA003980; -; . MIM 600953; gene; . neXtProt NX_Q14116; -; . OpenTargets ENSG00000150782; -; . PharmGKB PA29802; -; . eggNOG ENOG410J3U9; Eukaryota; . eggNOG ENOG410ZGS8; LUCA; . GeneTree ENSGT00390000001053; -; . HOGENOM HOG000048723; -; . HOVERGEN HBG000388; -; . InParanoid Q14116; -; . KO K05482; -; . OMA VPGHDDK; -; . OrthoDB EOG091G0NGF; -; . PhylomeDB Q14116; -; . TreeFam TF336297; -; . Reactome R-HSA-448706; Interleukin-1 processing; . Reactome R-HSA-449147; Signaling by Interleukins; . Reactome R-HSA-6783783; Interleukin-10 signaling; . Reactome R-HSA-6785807; Interleukin-4 and 13 signaling; . SIGNOR Q14116; -; . EvolutionaryTrace Q14116; -; . GeneWiki Interleukin_18; -; . GenomeRNAi 3606; -; . PMAP-CutDB Q14116; -; . PRO PR:Q14116; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000150782; -; . CleanEx HS_IL18; -; . ExpressionAtlas Q14116; baseline and differential; . Genevisible Q14116; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0005125; F:cytokine activity; TAS:UniProtKB; . GO GO:0032148; P:activation of protein kinase B activity; IDA:BHF-UCL; . GO GO:0001525; P:angiogenesis; IDA:UniProtKB; . GO GO:0007267; P:cell-cell signaling; TAS:ProtInc; . GO GO:0071407; P:cellular response to organic cyclic compound; IDA:UniProtKB; . GO GO:0042033; P:chemokine biosynthetic process; TAS:UniProtKB; . GO GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL; . GO GO:0042253; P:granulocyte macrophage colony-stimulating factor biosynthetic process; TAS:UniProtKB; . GO GO:0006955; P:immune response; TAS:ProtInc; . GO GO:0006954; P:inflammatory response; IDA:UniProtKB; . GO GO:0042095; P:interferon-gamma biosynthetic process; TAS:UniProtKB; . GO GO:0042231; P:interleukin-13 biosynthetic process; TAS:UniProtKB; . GO GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL; . GO GO:0042094; P:interleukin-2 biosynthetic process; TAS:UniProtKB; . GO GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:UniProtKB; . GO GO:0000165; P:MAPK cascade; IMP:UniProtKB; . GO GO:0042104; P:positive regulation of activated T cell proliferation; IDA:UniProtKB; . GO GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IDA:BHF-UCL; . GO GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL; . GO GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL; . GO GO:0032740; P:positive regulation of interleukin-17 production; IDA:BHF-UCL; . GO GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISS:BHF-UCL; . GO GO:0032819; P:positive regulation of natural killer cell proliferation; IDA:BHF-UCL; . GO GO:0051142; P:positive regulation of NK T cell proliferation; IDA:BHF-UCL; . GO GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:BHF-UCL; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IDA:BHF-UCL; . GO GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:BHF-UCL; . GO GO:0045630; P:positive regulation of T-helper 2 cell differentiation; ISS:BHF-UCL; . GO GO:0034105; P:positive regulation of tissue remodeling; IC:BHF-UCL; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:CACAO; . GO GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB; . GO GO:0030431; P:sleep; ISS:UniProtKB; . GO GO:0042088; P:T-helper 1 type immune response; IDA:UniProtKB; . GO GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL; . GO GO:0042092; P:type 2 immune response; TAS:UniProtKB; . InterPro IPR015529; IL-18; . InterPro IPR000975; IL-1_fam; . InterPro IPR008996; IL1/FGF; . PANTHER PTHR10078:SF66; PTHR10078:SF66; 1; . Pfam PF00340; IL1; 1; . PIRSF PIRSF015162; Interleukin_18; 1; . PRINTS PR01933; INTRLEUKIN18; . SUPFAM SSF50353; SSF50353; 1; .

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